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KMID : 0361019960390010051
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Korean Journal of Otolaryngology - Head and Neck Surgery
1996 Volume.39 No. 1 p.51 ~ p.56
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Correlation Between Cellular Differentiation and Apoptosis in the Head and Neck Cancer
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Abstract
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The purpose of this study was to investigate the correlation of apoptosis to cellular differentiation of head and neck cancer. Fifty-seven cases of head and neck cancer were selected for this study. Direct immunoperoxidase detection of
digoxigenin-lableled genomic DNA was carried out to detect apoptotic bodies within the tumor tissues using ApopTag In Situ apoptosis detection kit (Oncor, USA). The numbers of apoptotic dodies observed in ten randomly chosen high power fields
were
counted and compared to cellular differentiation. The numbers of apoptotic bodies seen in tumors with less cellular differentiation was low, while apoptotic bodies were found more frequently in tumors with higher cellular differentiation
(p<0.05).
These
results suggest that the numbers of apoptotic bodies in the tumor tissues can make it possible presume indirectly the malignant potentiality of the tumor and will help us to understand the biologic behavior of head and neck cancer. (Korean J
Otolaryngol
39 : 1, 1996)
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